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REVIEW : The Nuclear Magnetic Resonance Revolution in Basic and Clinical Neuroscience

Department of Neurology Yale University School of Medicine New Haven, Connecticut

Nuclear magnetic resonance (NMR) methods for the noninvasive, chemically specific investigation of living tissue have proliferated in number and advanced greatly in power since the first NMR images of anatomy appeared in the 1970s. By 1994, about 50 different NMR measurements had become available for the study of normal and pathological brain. These include aspects of biochemistry, angiography, perfusion, activation- sensitive metabolic rates for glucose and oxygen, monitoring of function through activation-induced changes in blood flow and water diffusion, and normal and pathological anatomy with submillimeter resolution. At least as many more measurements of biomedical importance are under development. Neuroscience research and management of neurological illness will be profoundly affected by NMR methods as they mature and become routine. The Neuroscientist 1:84-94, 1995

Key Words: KEY WORDS Nuclear magnetic resonance • Magnetic resonance imaging • Magnetic resonance spectroscopy • Neurological disorders, Neuroscience

The Neuroscientist, Vol. 1, No. 2, 84-94 (1995)
DOI: 10.1177/107385849500100205


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