This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Finkbeiner, S. Search for Related Content PubMed Articles by Finkbeiner, S. Social Bookmarking                         What's this?

Calcium-mediated Gene Expression: Mechanism for Neuronal Plasticity and Survival

Calcium plays a central role in many proposed mechanisms of neuronal plasticity as well as neuronal death and degeneration. The observation that certain calcium channel antag onists dramatically protect neurons in a variety of neurological disease models has led to a general strategy for neuroprotection: broadly block calcium entry. However, emerging evidence suggests that calcium can promote neuronal survival and plasticity or death and degeneration, depending on the route of entry. Calcium may partly promote neuronal survival through the autocrine action of neurotrophins such as brain-derived neurotrophic factor. Calcium-mediated neurotrophin secretion may also promote synapse formation during development and in conditions of chronic abnormal neuronal activity such as ep ilepsy. A full understanding of these signal transduction pathways could lead to refined pharmacological strategies that minimize calcium's deadly effects and optimize its growth- and survival-promoting properties. The Neuroscientist 1:317-320,1995

Key Words: KEY WORDS Brain-derived neurotrophic factor • c-fos • Ras • Epilepsy • Stroke • Memory

The Neuroscientist, Vol. 1, No. 6, 317-320 (1995)
DOI: 10.1177/107385849500100603


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?