The Neuroscientist

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for free access to the SAGE eReference platform!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cohen, J. E.
Right arrow Articles by Fields, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cohen, J. E.
Right arrow Articles by Fields, R. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Neuroscientist, Vol. 10, No. 1, 12-17 (2004)
DOI: 10.1177/1073858403259440

Extracellular Calcium Depletion in Synaptic Transmission

Jonathan E. Cohen

R. Douglas Fields

National Institutes of Health National Institute for Child and Human Development Section on Nervous System Development and Plasticity fields{at}helix.nih.gov

Regulation of Ca2+ homeostasis in the extracellular space plays an important role in neuronal function. Several modeling studies and recent measurements have demonstrated that modest action potential or synaptic activity can result in a significant reduction in extracellular calcium ([Ca]o2+). Changes in [Ca]o 2+ can regulate intracellular signaling enzymes, such as Ca2+/calmodulin–dependent protein kinase II, and influence neuronal function at synaptic and nonsynaptic sites. The change in [Ca]o 2+ can affect several types of ion channels and neurotransmitter receptors and activate a Ca2+-sensitive receptor in neuronal membranes. Depletion of [Ca]o 2+ may function as an activity-dependent extracellular messenger that regulates nervous system function during development, learning, and disease.

Key Words: Cadherin • Calcium-sensitive receptor • CaMKII • Extracellular calcium • Long-term potentiation • Synaptic plasticity


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
R. A. Nichols, A. F. Dengler, E. M. Nakagawa, M. Bashkin, B. T. Paul, J. Wu, and G. M. Khan
A Constitutive, Transient Receptor Potential-like Ca2+ Influx Pathway in Presynaptic Nerve Endings Independent of Voltage-gated Ca2+ Channels and Na+/Ca2+ Exchange
J. Biol. Chem., December 7, 2007; 282(49): 36102 - 36111.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. R. Hardingham, N. J. Bannister, J. C. A. Read, K. D. Fox, G. E. Hardingham, and J. J. B. Jack
Extracellular calcium regulates postsynaptic efficacy through group 1 metabotropic glutamate receptors.
J. Neurosci., June 7, 2006; 26(23): 6337 - 6345.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Ren, Y. Momose-Sato, K. Sato, and J. J. Greer
Rhythmic Neuronal Discharge in the Medulla and Spinal Cord of Fetal Rats in the Absence of Synaptic Transmission
J Neurophysiol, January 1, 2006; 95(1): 527 - 534.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
A. Gerbino, W. C. Ruder, S. Curci, T. Pozzan, M. Zaccolo, and A. M. Hofer
Termination of cAMP signals by Ca2+ and G{alpha}i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations
J. Cell Biol., October 24, 2005; 171(2): 303 - 312.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. M. Hofer
Another dimension to calcium signaling: a look at extracellular calcium
J. Cell Sci., March 1, 2005; 118(5): 855 - 862.
[Abstract] [Full Text] [PDF]