This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (66) Citing Articles via Google Scholar Google Scholar Articles by Pellerin, L. Articles by Magistretti, P. J. Search for Related Content PubMed PubMed Citation Articles by Pellerin, L. Articles by Magistretti, P. J. Social Bookmarking                   What's this?

Neuroenergetics: Calling Upon Astrocytes to Satisfy Hungry Neurons

Institut de Physiologie, Université de Lausanne, SwitzerlandLuc.Pellerin{at}iphysiol.unil.ch

Pierre J. Magistretti

Institut de Physiologie, Université de Lausanne, Switzerland

Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity.

Key Words: Glucose • Lactate • Monocarboxylate transporters • Aerobic glycolysis • Brain energy metabolism

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. A. Gonzalez, L. T. Jensen, L. Fugger, and D. Burdakov Metabolism-Independent Sugar Sensing in Central Orexin Neurons Diabetes, October 1, 2008; 57(10): 2569 - 2576. [Abstract] [Full Text] [PDF]

				D. Lovatt, U. Sonnewald, H. S. Waagepetersen, A. Schousboe, W. He, J. H.-C. Lin, X. Han, T. Takano, S. Wang, F. J. Sim, et al. The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex J. Neurosci., November 7, 2007; 27(45): 12255 - 12266. [Abstract] [Full Text] [PDF]

				P. M. Martin, Y. Dun, B. Mysona, S. Ananth, P. Roon, S. B. Smith, and V. Ganapathy Expression of the Sodium-Coupled Monocarboxylate Transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in Retina Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 3356 - 3363. [Abstract] [Full Text] [PDF]

				J. M. Pascual, D. Wang, V. Hinton, K. Engelstad, C. M. Saxena, R. L. Van Heertum, and D. C. De Vivo Brain Glucose Supply and the Syndrome of Infantile Neuroglycopenia Arch Neurol, April 1, 2007; 64(4): 507 - 513. [Abstract] [Full Text] [PDF]

				S. M. Mense, A. Sengupta, M. Zhou, C. Lan, G. Bentsman, D. J. Volsky, and L. Zhang Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes Physiol Genomics, May 16, 2006; 25(3): 435 - 449. [Abstract] [Full Text] [PDF]

				R. C. Koehler, D. Gebremedhin, and D. R. Harder Role of astrocytes in cerebrovascular regulation J Appl Physiol, January 1, 2006; 100(1): 307 - 317. [Abstract] [Full Text] [PDF]

				M. V. Sofroniew Reactive Astrocytes in Neural Repair and Protection Neuroscientist, October 1, 2005; 11(5): 400 - 407. [Abstract] [PDF]

				M. Yudkoff, Y. Daikhin, I. Nissim, O. Horyn, B. Luhovyy, A. Lazarow, and I. Nissim Brain Amino Acid Requirements and Toxicity: The Example of Leucine J. Nutr., June 1, 2005; 135(6): 1531S - 1538S. [Abstract] [Full Text] [PDF]

				G. J. Menger, K. Lu, T. Thomas, V. M. Cassone, and D. J. Earnest Circadian profiling of the transcriptome in immortalized rat SCN cells Physiol Genomics, May 11, 2005; 21(3): 370 - 381. [Abstract] [Full Text] [PDF]

				A. Charles Reaching Out Beyond the Synapse: Glial Intercellular Waves Coordinate Metabolism Sci. Signal., February 8, 2005; 2005(270): pe6 - pe6. [Abstract] [Full Text] [PDF]