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The Neuroscientist, Vol. 10, No. 1,
53-62 (2004)
DOI: 10.1177/1073858403260159
Neuroenergetics: Calling Upon Astrocytes to Satisfy Hungry Neurons
Luc Pellerin
Institut de Physiologie, Université de Lausanne, SwitzerlandLuc.Pellerin{at}iphysiol.unil.ch
Pierre J. Magistretti
Institut de Physiologie, Université de Lausanne, Switzerland
Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity.
Key Words: Glucose Lactate Monocarboxylate transporters Aerobic glycolysis Brain energy metabolism

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