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Neuroenergetics: Calling Upon Astrocytes to Satisfy Hungry Neurons

Institut de Physiologie, Université de Lausanne, SwitzerlandLuc.Pellerin{at}iphysiol.unil.ch

Pierre J. Magistretti

Institut de Physiologie, Université de Lausanne, Switzerland

Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity.

Key Words: Glucose • Lactate • Monocarboxylate transporters • Aerobic glycolysis • Brain energy metabolism

The Neuroscientist, Vol. 10, No. 1, 53-62 (2004)
DOI: 10.1177/1073858403260159


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