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The Neuroscientist, Vol. 10, No. 2, 99-105 (2004)
DOI: 10.1177/1073858403260751
© 2004 SAGE Publications

Oligodendrocyte Precursors on the Move: Mechanisms Directing Migration

Andrew A. Jarjour

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

Timothy E. Kennedy

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, timothy.kennedy{at}mcgill.ca

Oligodendrocyte precursor cells traverse long distances to reach their axonal targets. The molecules that influence their migration include a combination of short-range attractants and repellents and long-range chemoattractants and chemorepellents. Here, the authors review mechanisms that direct oligodendrocyte precursor cells as they migrate throughout the developing CNS.

Key Words: Motility • Laminin • Fibronectin • Vitronectin • Tenascin • Collagen • Netrin • Semaphorin • PDGF • FGF • HGF


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