SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
The Neuroscientist
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (10)
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Popescu, G.
Right arrow Articles by Auerbach, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Popescu, G.
Right arrow Articles by Auerbach, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

The NMDA Receptor Gating Machine: Lessons from Single Channels

Gabriela Popescu

Department of Physiology and Biophysics Center for Single Molecule Biophysics University at Buffalo, popescu{at}buffalo.edu

Anthony Auerbach

Department of Physiology and Biophysics Center for Single Molecule Biophysics University at Buffalo

The slow component of the excitatory postsynaptic current in the central nervous system is generated by the activity of NMDA receptors. The activation properties of this class of glutamate receptor determine key features of the synaptic response and have important consequences for synaptic plasticity and cell physiology. NMDA receptor activation is complex and involves ligand binding, protein conformational changes, and channel blockade. Recently, two groups have proposed state models that encapsulate the essential features of NMDA receptor gating conformational changes. These models provide insight into the NMDA receptor as a molecular machine and should help us understand and manipulate NMDA receptor mediated synaptic function and pathologies.

Key Words: NMDA receptor • Synapse • Gating • Kinetics • Models • Single channels • Patch clamp

The Neuroscientist, Vol. 10, No. 3, 192-198 (2004)
DOI: 10.1177/1073858404263483
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JGPHome page
A. Keramidas and N. L. Harrison
Agonist-dependent Single Channel Current and Gating in {alpha}4{beta}2{delta} and {alpha}1{beta}2{gamma}2S GABAA Receptors
J. Gen. Physiol., January 28, 2008; 131(2): 163 - 181.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
L. Ionescu, C. White, K.-H. Cheung, J. Shuai, I. Parker, J. E. Pearson, J. K. Foskett, and D.-O. D. Mak
Mode Switching Is the Major Mechanism of Ligand Regulation of InsP3 Receptor Calcium Release Channels
J. Gen. Physiol., November 26, 2007; 130(6): 631 - 645.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. J. Gibb
Glutamate unbinding reveals new insights into NMDA receptor activation
J. Physiol., July 15, 2006; 574(2): 329 - 329.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Auerbach and Y. Zhou
Gating Reaction Mechanisms for NMDA Receptor Channels
J. Neurosci., August 31, 2005; 25(35): 7914 - 7923.
[Abstract] [Full Text] [PDF]


Advertisement