SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
The Neuroscientist
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (6)
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Burdakov, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Burdakov, D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Electrical Signaling in Central Orexin/Hypocretin Circuits: Tuning Arousal and Appetite to Fit the Environment

Denis Burdakov

University Laboratory of Physiology University of Oxford

In mammals, alertness and foraging are linked to the light-dark cycle and body energy levels. This link is crucially dependent on the novel peptide transmitters orexins/hypocretins. The firing of orexin neurons encodes the overall internal (body energy levels) and external (time of day) environment. In turn, orexins modulate arousal and appetite by innervating and electrically exciting wakeand appetitepromoting neurons. Electrical signaling in orexin circuits thereby couples arousal to the environment and synchronizes foraging with states of high alertness.

Key Words: Arousal • Sleep • Hypothalamus • Energy balance • Orexin • Hypocretin

The Neuroscientist, Vol. 10, No. 4, 286-291 (2004)
DOI: 10.1177/1073858404263597
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. F. Doane, M. A. Lawson, J. R. Meade, C. M. Kotz, and J. L. Beverly
Orexin-induced feeding requires NMDA receptor activation in the perifornical region of the lateral hypothalamus
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1022 - R1026.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. H. Williams, L. T. Jensen, A. Verkhratsky, L. Fugger, and D. Burdakov
Control of hypothalamic orexin neurons by acid and CO2
PNAS, June 19, 2007; 104(25): 10685 - 10690.
[Abstract] [Full Text] [PDF]


Advertisement