The Neuroscientist

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ron, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ron, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Neuroscientist, Vol. 10, No. 4, 325-336 (2004)
DOI: 10.1177/1073858404263516
© 2004 SAGE Publications

Reviews

Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol

Dorit Ron

Department of Neurology, University of California, San Francisco Ernest Gallo Clinic and Research Center

One of the major targets for ethanol (alcohol) in the brain is the N-methyl-D-aspartate (NMDA) receptor, a glutamate-gated ion channel. Intriguingly, the effects of ethanol on the NMDA receptor are not homogeneous throughout the brain. This review focuses on recent studies revealing molecular mechanisms that mediate the actions of ethanol on the NMDA receptor in different brain regions via changes in NMDA receptor phosphorylation and compartmentalization. Specifically, the role of the scaffolding protein RACK1 and the regulatory protein DARPP-32 in mediating the distinct effects of ethanol is presented.

Key Words: N-methyl-D-aspartate (NMDA) • Ethanol • Phosphorylation • RACK1 • DARPP-32


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
R. Jurd, C. Thornton, J. Wang, K. Luong, K. Phamluong, V. Kharazia, S. L. Gibb, and D. Ron
Mind Bomb-2 Is an E3 Ligase That Ubiquitinates the N-Methyl-D-aspartate Receptor NR2B Subunit in a Phosphorylation-dependent Manner
J. Biol. Chem., January 4, 2008; 283(1): 301 - 310.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Wang, S. Carnicella, K. Phamluong, J. Jeanblanc, J. A. Ronesi, N. Chaudhri, P. H. Janak, D. M. Lovinger, and D. Ron
Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior
J. Neurosci., March 28, 2007; 27(13): 3593 - 3602.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
D. Ron and R. Jurd
The "Ups and Downs" of Signaling Cascades in Addiction
Sci. Signal., November 8, 2005; 2005(309): re14 - re14.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Suvarna, S. L. Borgland, J. Wang, K. Phamluong, Y. P. Auberson, A. Bonci, and D. Ron
Ethanol Alters Trafficking and Functional N-Methyl-D-aspartate Receptor NR2 Subunit Ratio via H-Ras
J. Biol. Chem., September 9, 2005; 280(36): 31450 - 31459.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
C. R. Goodlett, K. H. Horn, and F. C. Zhou
Alcohol Teratogenesis: Mechanisms of Damage and Strategies for Intervention
Experimental Biology and Medicine, June 1, 2005; 230(6): 394 - 406.
[Abstract] [Full Text] [PDF]