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Cortical Up and Activated States: Implications for Sensory Information Processing

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania

^* To whom correspondence should be addressed. E-mail: mcastro{at}drexelmed.edu.

	Abstract

The neocortex generates spontaneous slow oscillations that consist of up and down states during quiescence. Up states are short epochs of persistent activity that resemble the state of cortical activation during arousal and cognition. The excitability of cortical cells and synaptic networks is impacted by up states. This review describes the characteristics and putative functional role of up states and their similarity with activated states.

First published on March 24, 2009
The Neuroscientist 2009, doi:10.1177/1073858409333074


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