This Article Full Text (OnlineFirst PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Timofeev, I. Articles by Nita, D. A. Search for Related Content PubMed PubMed Citation Articles by Timofeev, I. Articles by Nita, D. A. Social Bookmarking                         What's this?

Posttraumatic Epilepsy: The Roles of Synaptic Plasticity

¹ Laval University, Medical School, Centre de Recherche Université Laval Robert-Giffard, Québec, Québec, Canada
² Department of Cell Biology and Neuroscience, University of California Riverside, California

^* To whom correspondence should be addressed. E-mail: Igor.Timofeev{at}phs.ulaval.ca.

	Abstract

Acute cerebral cortical trauma often leads to paroxysmal activities that terminate in a few hours, but several months later, patients can develop epilepsy. The process occurring between the initial acute triggered seizures and the onset of spontaneous unprovoked seizures is termed epileptogenesis. Here the authors summarize recent morphological, electrophysiological, and computational studies demonstrating that partial cortical isolation increases the number and duration of silent states in the cortical network, boosting neuronal connectivity and network excitability. These changes develop progressively, and after several weeks their synergetic action leads to epilepsy.

First published on April 9, 2009
The Neuroscientist 2009, doi:10.1177/1073858409333545


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?