The Neuroscientist

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rabiner, C. A.
Right arrow Articles by Eipper, B. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rabiner, C. A.
Right arrow Articles by Eipper, B. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Neuroscientist, Vol. 11, No. 2, 148-160 (2005)
DOI: 10.1177/1073858404271250
© 2005 SAGE Publications

Reviews

Kalirin: A Dual Rho Guanine Nucleotide Exchange Factor That Is So Much More Than the Sum of Its Many Parts

Chana A. Rabiner

Department of Neuroscience, University of Connecticut Health Center

Richard E. Mains

Department of Neuroscience, University of Connecticut Health Center

Betty A. Eipper

Department of Neuroscience, University of Connecticut Health Center, eipper{at}nso.uchc.edu

A large number of Rho guanine nucleotide exchange factors (GEFs) and Rho GTPase activating proteins (GAPs) are used in the CNS to activate specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, in part through their effects on the actin cytoskeleton. Kalirin is a large neuronal dual Rho GEF that activates Rac1, RhoA, and RhoG via its two Rho GEF domains. This activation, which is spatially and temporally regulated, allows Kalirin to influence neurite initiation, axonal growth, and dendritic morphogenesis. In addition, this alternatively spliced gene generates developmentally regulated transcripts that yield proteins localized to the postsynaptic density (PSD). Kalirin-7, which interacts with PSD-95, is necessary for dendritic spine formation. In addition, Kalirins have the ability to regulate and influence other aspects of neuronal morphogenesis via protein-protein interactions with their other domains, including many spectrins, other protein and lipid interaction domains, and a potential kinase. These interactions have implications not only for neuronal morphogenesis but also for vesicle trafficking, secretion, neuronal maintenance, and neurodegenerative disease.

Key Words: Rho GTPase • Trio • Spine formation • Alternative splicing • Postsynaptic density • Secretion • iNOS


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
J. Meller, L. Vidali, and M. A. Schwartz
Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration
J. Cell Sci., June 15, 2008; 121(12): 1981 - 1989.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. J. Rojas, M. E. Yohe, S. Gershburg, T. Kawano, T. Kozasa, and J. Sondek
G{alpha}q Directly Activates p63RhoGEF and Trio via a Conserved Extension of the Dbl Homology-associated Pleckstrin Homology Domain
J. Biol. Chem., October 5, 2007; 282(40): 29201 - 29210.
[Abstract] [Full Text] [PDF]