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Rho Family GTPases and Dendrite Plasticity

Laboratory of Molecular Neurobiology, Graduate School of Biostudies Kyoto University, mnegishi{at}pharm.kyoto-u.ac.jp

Hironori Katoh

Laboratory of Molecular Neurobiology, Graduate School of Biostudies Kyoto University

Dendrite structures exert a profound influence on neuronal information processing. The Rho family GTPases have been implicated in the regulation of dendritic development. Among them, Rho, Rac, and Cdc42 have been characterized extensively, and Rac and Cdc42 promote dendrite growth and branching, whereas Rho acts as a negative regulator for dendrite growth. Recently, other members of Rho family GTPases, including Rnd1 and Rnd2, have also been shown to be involved in the regulation of dendrite development. Rnd1 promotes spine maturation, and Rnd2 stimulates dendrite branching through its specific effector, Rapostlin. Thus, a variety of Rho family GTPases play important roles in dendritic development.

Key Words: Rho • Rnd • Dendrite • Spine • Mental retardation

The Neuroscientist, Vol. 11, No. 3, 187-191 (2005)
DOI: 10.1177/1073858404268768


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