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Neurogenesis in the Adult Ischemic Brain: Generation, Migration, Survival, and Restorative Therapy
Rui Lan Zhang
Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan
Zheng Gang Zhang
Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan
Michael Chopp
Department of Physics, Oakland University, Rochester, Michigan, chopp{at}neuro.hfh.edu
This article reviews current data on the induction of neurogenesis after stroke in the adult brain. The discussion of neurogenesis is divided into production, migration, and survival of these newly formed cells. For production, the subpopulations and the types of cell division are presented. Discussion of cell migration entails presenting data on both the pathways as well as the molecular targeting of newly formed neural progenitor cells to sites of injury. The role of the vascular and the astrocytic microenvironment in promoting the survival and integration of progenitor cells is also presented. Cell-based and pharmacological therapies designed to restore neurological function that promote neurogenesis are described. These therapies also induce angiogenesis and astrocytic changes that brain tissue, which prime the ischemic brain to foster the survival of the newly formed progenitor cells. Signaling pathways that regulate neurogenesis and angiogenesis are also addressed. This review summarizes recent data on neurogenesis and provides insight into the potential for restorative treatments of stroke.
Key Words: Cerebral ischemia • Neurogenesis • Angiogenesis • Restoration therapy
The Neuroscientist, Vol. 11, No. 5,
408-416 (2005)
DOI: 10.1177/1073858405278865
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