This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (38) Citing Articles via Google Scholar Google Scholar Articles by Zhang, R. L. Articles by Chopp, M. Search for Related Content PubMed PubMed Citation Articles by Zhang, R. L. Articles by Chopp, M. Social Bookmarking                   What's this?

Neurogenesis in the Adult Ischemic Brain: Generation, Migration, Survival, and Restorative Therapy

Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan

Zheng Gang Zhang

Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan

Michael Chopp

Department of Physics, Oakland University, Rochester, Michigan, chopp{at}neuro.hfh.edu

This article reviews current data on the induction of neurogenesis after stroke in the adult brain. The discussion of neurogenesis is divided into production, migration, and survival of these newly formed cells. For production, the subpopulations and the types of cell division are presented. Discussion of cell migration entails presenting data on both the pathways as well as the molecular targeting of newly formed neural progenitor cells to sites of injury. The role of the vascular and the astrocytic microenvironment in promoting the survival and integration of progenitor cells is also presented. Cell-based and pharmacological therapies designed to restore neurological function that promote neurogenesis are described. These therapies also induce angiogenesis and astrocytic changes that brain tissue, which prime the ischemic brain to foster the survival of the newly formed progenitor cells. Signaling pathways that regulate neurogenesis and angiogenesis are also addressed. This review summarizes recent data on neurogenesis and provides insight into the potential for restorative treatments of stroke.

Key Words: Cerebral ischemia • Neurogenesis • Angiogenesis • Restoration therapy

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. T. Carmichael Themes and Strategies for Studying the Biology of Stroke Recovery in the Poststroke Epoch Stroke, April 1, 2008; 39(4): 1380 - 1388. [Abstract] [Full Text] [PDF]

				M. Cimino, P. Gelosa, A. Gianella, E. Nobili, E. Tremoli, and L. Sironi Statins: Multiple Mechanisms of Action in the Ischemic Brain Neuroscientist, June 1, 2007; 13(3): 208 - 213. [Abstract] [PDF]

				M. Chopp, Z. G. Zhang, and Q. Jiang Neurogenesis, Angiogenesis, and MRI Indices of Functional Recovery From Stroke Stroke, February 1, 2007; 38(2): 827 - 831. [Abstract] [Full Text] [PDF]

				B. H. Dobkin Behavioral, Temporal, and Spatial Targets for Cellular Transplants as Adjuncts to Rehabilitation for Stroke Stroke, February 1, 2007; 38(2): 832 - 839. [Abstract] [Full Text] [PDF]

				J. Nygren, T. Wieloch, J. Pesic, P. Brundin, and T. Deierborg Enriched Environment Attenuates Cell Genesis in Subventricular Zone After Focal Ischemia in Mice and Decreases Migration of Newborn Cells to the Striatum Stroke, November 1, 2006; 37(11): 2824 - 2829. [Abstract] [Full Text] [PDF]

				L. Wang, Z. G. Zhang, R. L. Zhang, S. R. Gregg, A. Hozeska-Solgot, Y. LeTourneau, Y. Wang, and M. Chopp Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration. J. Neurosci., May 31, 2006; 26(22): 5996 - 6003. [Abstract] [Full Text] [PDF]

				S.-R. Lee, H.-Y. Kim, J. Rogowska, B.-Q. Zhao, P. Bhide, J. M. Parent, and E. H. Lo Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke. J. Neurosci., March 29, 2006; 26(13): 3491 - 3495. [Abstract] [Full Text] [PDF]