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The Neuroscientist, Vol. 11, No. 5, 494-502 (2005)
DOI: 10.1177/1073858405278236

Reviews

Psychostimulants, L-type Calcium Channels, Kinases, and Phosphatases

Anjali M. Rajadhyaksha

Labortory of Molecular and Developmental Neuroscience, and Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, rajadhan{at}helix.mgh.harvard.edu

Barry E. Kosofsky

Department of Pediatrics, Division of Pediatric Neurology, New York Presbyterian Hospital, Weill Conell Medical College, New York, New York

There is growing evidence for the role of voltage-gated L-type Ca2+ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca2+ channels activate Ca2+ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression. Here the authors will review recent progress in our understanding of L-type Ca2+ channel-activated signal transduction pathways that contribute to molecular neuroadaptations evident following acute and chronic exposures to psychostimulants.

Key Words: Drug addiction • Cav1.2 • Cav1.3 • Ventral tegmental area • Nucleus accumbens • Striatum • Phosphorylation


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