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Potassium Channels, Memory T Cells, and Multiple Sclerosis

Department of Physiology and Biophysics, Medical School, University of California, Irvine

K. George Chandy

Department of Physiology and Biophysics, Medical School, 346-D Med. Sci. I, University of California, Irvine, Irvine, CA 92697 gchandy{at}uci.edu

Multiple sclerosis is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal damage that result in disabling neurological deficits. Here the authors explain the rationale for the use of inhibitors of the Kv1.3 K⁺ channel in immune cells as a therapy for multiple sclerosis and other autoimmune disorders.

Key Words: Potassium channels • Memory lymphocytes • Autoimmunity • Multiple sclerosis • Kv1.3

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