|
Sign In to gain access to subscriptions and/or personal tools.
|
Potassium Channels, Memory T Cells, and Multiple Sclerosis
Christine Beeton
Department of Physiology and Biophysics, Medical School, University of California, Irvine
K. George Chandy
Department of Physiology and Biophysics, Medical School, 346-D Med. Sci. I, University of California, Irvine, Irvine, CA 92697 gchandy{at}uci.edu
Multiple sclerosis is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal damage that result in disabling neurological deficits. Here the authors explain the rationale for the use of inhibitors of the Kv1.3 K+ channel in immune cells as a therapy for multiple sclerosis and other autoimmune disorders.
Key Words: Potassium channels Memory lymphocytes Autoimmunity Multiple sclerosis Kv1.3
The Neuroscientist, Vol. 11, No. 6,
550-562 (2005)
DOI: 10.1177/1073858405278016

CiteULike Complore Connotea Del.icio.us Digg Reddit Technorati Twitter What's this?
This article has been cited by other articles:

|
 |

|
 |
 
L. Sole, M. Roura-Ferrer, M. Perez-Verdaguer, A. Oliveras, M. Calvo, J. M. Fernandez-Fernandez, and A. Felipe
KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating
J. Cell Sci.,
October 15, 2009;
122(20):
3738 - 3748.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. AKAMATSU, M.-A. SHIBATA, Y. ITO, Y. SOHMA, H. AZUMA, and Y. OTSUKI
Riluzole Induces Apoptotic Cell Death in Human Prostate Cancer Cells via Endoplasmic Reticulum Stress
Anticancer Res,
June 1, 2009;
29(6):
2195 - 2204.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Han, H. Yi, S.-J. Yin, Z.-Y. Chen, H. Liu, Z.-J. Cao, Y.-L. Wu, and W.-X. Li
Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease
J. Biol. Chem.,
July 4, 2008;
283(27):
19058 - 19065.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. G. Meuth, S. Bittner, P. Meuth, O. J. Simon, T. Budde, and H. Wiendl
TWIK-related Acid-sensitive K+ Channel 1 (TASK1) and TASK3 Critically Influence T Lymphocyte Effector Functions
J. Biol. Chem.,
May 23, 2008;
283(21):
14559 - 14570.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Vicente, N. Villalonga, M. Calvo, A. Escalada, C. Solsona, C. Soler, M. M. Tamkun, and A. Felipe
Kv1.5 Association Modifies Kv1.3 Traffic and Membrane Localization
J. Biol. Chem.,
March 28, 2008;
283(13):
8756 - 8764.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. E. Pereira, F. Villinger, H. Wulff, A. Sankaranarayanan, G. Raman, and A. A. Ansari
Pharmacokinetics, Toxicity, and Functional Studies of the Selective Kv1.3 Channel Blocker 5-(4-Phenoxybutoxy)Psoralen in Rhesus Macaques
Experimental Biology and Medicine,
November 1, 2007;
232(10):
1338 - 1354.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. H. Nam, H.-S. Lee, Y. H. Nguyen, T. M. Kang, S. W. Lee, H.-Y. Kim, S. J. Kim, Y. E. Earm, and S. J. Kim
Mechanosensitive activation of K+ channel via phospholipase C-induced depletion of phosphatidylinositol 4,5-bisphosphate in B lymphocytes
J. Physiol.,
August 1, 2007;
582(3):
977 - 990.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Vicente, A. Escalada, N. Villalonga, L. Texido, M. Roura-Ferrer, M. Martin-Satue, C. Lopez-Iglesias, C. Soler, C. Solsona, M. M. Tamkun, et al.
Association of Kv1.5 and Kv1.3 Contributes to the Major Voltage-dependent K+ Channel in Macrophages
J. Biol. Chem.,
December 8, 2006;
281(49):
37675 - 37685.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Beeton, H. Wulff, N. E. Standifer, P. Azam, K. M. Mullen, M. W. Pennington, A. Kolski-Andreaco, E. Wei, A. Grino, D. R. Counts, et al.
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
PNAS,
November 14, 2006;
103(46):
17414 - 17419.
[Abstract]
[Full Text]
[PDF]
|
 |
|
|
|