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Regulation of Cortical Interneurons by Neurotrophins: From Development to Cognitive Disorders

Section on Neural Development & Plasticity, NICHD, Bethesda, MD

Bai Lu

Section on Neural Development & Plasticity, NICHD, and the Genes, Cognition and Psychosis Program (GCAP), NIMH, NIH, Bethesda, MD, bailu{at}mail.nih.gov

Parvalbumin-positive interneurons, which include basket and chandelier cells, represent a unique class of interneurons. By innervating the soma and the axonal initial segment of pyramidal cells, these interneurons can elicit powerful control on the output of pyramidal cells and consequently are important for a number of physiological processes in the mammalian brain. Recent evidence indicates that neurotrophins regulate the development and functions of parvalbumin-positive interneurons. Disruption of neurotrophin-mediated regulation of interneurons is thought to contribute to the pathological processes underlying CNS dysfunction. This review brings together recently described roles of neurotrophins in migration, differentiation, synaptogenesis during development, and acute effects of neurotrophins in transmission at inhibitory synapses, Cl^- homeostasis, and network activity of cortical interneurons. The authors also discuss the importance of neurotrophin regulation of GABAergic neurons in schizophrenia and epilepsy.

Key Words: Parvalbumin • Basket cells • Chandelier cells • Axo-axonic • Epilepsy • Schizophrenia • GABA • BDNF

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