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The Neuroscientist
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Neuropathological and Genetic Findings in Autism: The Significance of a Putative Minicolumnopathy

Manuel F. Casanova

Department of Psychiatry and Behavioral Sciences University of Louisville, Louisville, Kentucky

Autism is a condition manifested as abnormalities of relatedness, communication, range of interests, and repetitive behaviors. Despite alarming prevalence estimates and exhortations to research, little is known regarding its pathophysiology. Recent reports of a putative minicolumnopathy explain changes in brain size, gray/white matter ratios, and interareal connectivity. This article summarizes possible links between minicolumns and other topics—cortical modularity, age of onset, gliosis, and genetics—relevant to the pathophysiology of autism.

Key Words: Autistic disorder/pathology • Child development disorders • Pervasive • Neocortex • Neuropil • Pyramidal cells

The Neuroscientist, Vol. 12, No. 5, 435-441 (2006)
DOI: 10.1177/1073858406290375
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This article has been cited by other articles:


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