This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (46) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Nishiyama, A. Search for Related Content PubMed PubMed Citation Articles by Nishiyama, A. Social Bookmarking                         What's this?

Polydendrocytes: NG2 Cells with Many Roles in Development and Repair of the CNS

Department of Physiology and Neurobiology, University of Connecticut

NG2 cells, or polydendrocytes, are defined as glial cells that express the NG2 proteoglycan and represent a fourth major glial cell population in the mammalian central nervous system. They are morphologically, antigenically, and functionally distinct from mature astrocytes, oligodendrocytes, and microglia. Although they are most often equated with oligodendrocyte progenitor cells, they exhibit some properties that are not commonly associated with those of progenitor cells that generate myelinating cells. This review discusses recent observations and unanswered issues related to their lineage and their role in remyelination, neural signaling, and axonal growth.

Key Words: NG2 • Oligodendrocyte progenitor • Remyelination • Axon • Astrocyte • AMPA receptor • Cell lineage

The Neuroscientist, Vol. 13, No. 1, 62-76 (2007)
DOI: 10.1177/1073858406295586


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. T. Fu, T. Tran, and D. Sretavan Axonal/Glial Upregulation of EphB/ephrin-B Signaling in Mouse Experimental Ocular Hypertension Invest. Ophthalmol. Vis. Sci., February 1, 2010; 51(2): 991 - 1001. [Abstract] [Full Text] [PDF]

				A. Mela and J. E. Goldman The Tetraspanin KAI1/CD82 Is Expressed by Late-Lineage Oligodendrocyte Precursors and May Function to Restrict Precursor Migration and Promote Oligodendrocyte Differentiation and Myelination J. Neurosci., September 9, 2009; 29(36): 11172 - 11181. [Abstract] [Full Text] [PDF]

				W.-P. Ge, W. Zhou, Q. Luo, L. Y. Jan, and Y. N. Jan Dividing glial cells maintain differentiated properties including complex morphology and functional synapses PNAS, January 6, 2009; 106(1): 328 - 333. [Abstract] [Full Text] [PDF]

				L. Dimou, C. Simon, F. Kirchhoff, H. Takebayashi, and M. Gotz Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex J. Neurosci., October 8, 2008; 28(41): 10434 - 10442. [Abstract] [Full Text] [PDF]

				A. Chang, M. C. Smith, X. Yin, R. J. Fox, S. M. Staugaitis, and B. D. Trapp Neurogenesis in the chronic lesions of multiple sclerosis Brain, September 1, 2008; 131(9): 2366 - 2375. [Abstract] [Full Text] [PDF]

				M. Kukley, M. Kiladze, R. Tognatta, M. Hans, D. Swandulla, J. Schramm, and D. Dietrich Glial cells are born with synapses FASEB J, August 1, 2008; 22(8): 2957 - 2969. [Abstract] [Full Text] [PDF]

				N. Chatterjee, J. Stegmuller, P. Schatzle, K. Karram, M. Koroll, H. B. Werner, K.-A. Nave, and J. Trotter Interaction of Syntenin-1 and the NG2 Proteoglycan in Migratory Oligodendrocyte Precursor Cells J. Biol. Chem., March 28, 2008; 283(13): 8310 - 8317. [Abstract] [Full Text] [PDF]