This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Blumenfeld, R. S. Articles by Ranganath, C. Search for Related Content PubMed PubMed Citation Articles by Blumenfeld, R. S. Articles by Ranganath, C. Social Bookmarking                   What's this?

Prefrontal Cortex and Long-Term Memory Encoding: An Integrative Review of Findings from Neuropsychology and Neuroimaging

Center for Neuroscience and Department of Psychology, University of California at Davis, roblume @ucdavis.edu

Charan Ranganath

Center for Neuroscience and Department of Psychology, University of California at Davis

Recent findings have led to a growing appreciation of the role of the lateral prefrontal cortex (PFC) in episodic long-term memory (LTM). Here, the authors will review results from neuropsychological and neuroimaging studies of humans and present a framework to explain how different regions of the PFC contribute to successful LTM formation. Central to this framework is the idea that different regions within the PFC implement different control processes that augment memory by enhancing or attenuating memory for certain aspects of a particular item or event. Evidence reviewed here suggests that ventrolateral regions of the PFC contribute to the ability to select goal-relevant item information, and that this processing strengthens the representation of goal-relevant features of items during LTM encoding. Dorsolateral regions of the PFC may contribute to the ability to organize multiple pieces of information in working memory, thereby enhancing memory for associations among items in LTM. Thus, dorsolateral and ventrolateral regions of the PFC may implement different control processes that support LTM formation in a complementary fashion. NEUROSCIENTIST 13(3):280—291, 2007.

Key Words: Working • Organization • Selection • Frontal • Lobes • Associative • Episodic • Memory

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. E. Hannula and C. Ranganath Medial Temporal Lobe Activity Predicts Successful Relational Memory Binding J. Neurosci., January 2, 2008; 28(1): 116 - 124. [Abstract] [Full Text] [PDF]