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The Neuroscientist
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Remyelination of the Central Nervous System: A Valuable Contribution from the Periphery

Violetta Zujovic

Institut National de la Santé et de la Recherche Médicale, Université Pierre et Marie Curie, and AP-HP Hôpital Pitié-Salpêtrière, Fédération de Neurologie, Paris, France

Corinne Bachelin

Institut National de la Santé et de la Recherche Médicale, Université Pierre et Marie Curie, and AP-HP Hôpital Pitié-Salpêtrière, Fédération de Neurologie, Paris, France

Anne Baron-Van Evercooren

Institut National de la Santé et de la Recherche Médicale, Université Pierre et Marie Curie, and AP-HP Hôpital Pitié-Salpêtrière, Fédération de Neurologie, Paris, France, baron{at}ccr.jussieu.fr

The loss of myelin, a major element involved in the saltatory conduction of the electrical impulse of the nervous system, is a major target of current research. Serious long-term disabilities are observed in patients with demyelinating disease of the central nervous system, such as multiple sclerosis. New therapeutic strategies aimed at overcoming myelin damage and axonal loss focus on the repair potential of myelin-forming cells. This review examines the use of peripheral myelin-forming cells, the Schwann cells, to promote myelin repair. NEUROSCIENTIST 13(4):383—391, 2007. DOI: 10.1177/1073858407300762

Key Words: Remyelination • CNS • Schwann cells • Multiple sclerosis

The Neuroscientist, Vol. 13, No. 4, 383-391 (2007)
DOI: 10.1177/10738584070130041001
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