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Cerebral Disconnectivity: An Early Event in SchizophreniaDepartment of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Bern, Switzerland, stefan.begre{at}insel.ch
Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, Bern, Switzerland Neuroimaging and electrophysiological investigations have demonstrated numerous differences in brain morphology and function of chronic schizophrenia patients compared to healthy controls. Studying patients at the beginning of their disease without the confounding effects of chronicity, medication, and institutionalization may provide a better understanding of schizophrenia. Recently, at many institutions around the world, special projects have been launched for specialized treatment and research of this interesting patient group. Using the PubMed search engine in this update, the authors summarize recent investigations between January 2002 and September 2006 that focus on whether signs of disconnectivity already exist early in the disease process. They discuss gray and white matter changes, their impact on symptomatology, electroencephalogram-based studies on connectivity, and possible influences of medication. NEUROSCIENTIST 14(1):19—45, 2008. DOI: 10.1177/1073858406298391
Key Words: First-episode schizophrenia • First-episode psychosis • Connectivity • Disconnectivity • MRI • EEG
This version was published on February
1, 2008 The Neuroscientist, Vol. 14, No. 1,
19-45 (2008) This article has been cited by other articles:
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