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This version was published on February 1, 2008
The Neuroscientist, Vol. 14, No. 1, 19-45 (2008)
DOI: 10.1177/1073858406298391
© 2008 SAGE Publications

Cerebral Disconnectivity: An Early Event in Schizophrenia

S. Begré

Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Bern, Switzerland, stefan.begre{at}insel.ch

T. Koenig

Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, Bern, Switzerland

Neuroimaging and electrophysiological investigations have demonstrated numerous differences in brain morphology and function of chronic schizophrenia patients compared to healthy controls. Studying patients at the beginning of their disease without the confounding effects of chronicity, medication, and institutionalization may provide a better understanding of schizophrenia. Recently, at many institutions around the world, special projects have been launched for specialized treatment and research of this interesting patient group. Using the PubMed search engine in this update, the authors summarize recent investigations between January 2002 and September 2006 that focus on whether signs of disconnectivity already exist early in the disease process. They discuss gray and white matter changes, their impact on symptomatology, electroencephalogram-based studies on connectivity, and possible influences of medication. NEUROSCIENTIST 14(1):19—45, 2008. DOI: 10.1177/1073858406298391

Key Words: First-episode schizophrenia • First-episode psychosis • Connectivity • Disconnectivity • MRI • EEG


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