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This version was published on February 1, 2008
The Neuroscientist, Vol. 14, No. 1, 46-52 (2008)
DOI: 10.1177/1073858407308889

Gender-Related Differences in Apoptotic Pathways After Neonatal Cerebral Ischemia

Sylvain Renolleau

Université Pierre et Marie Curie–Paris, France, Service de Réanimation Néonatale et Pédiatrique, Hôpital Armand Trousseau, Université Pierre et Marie Curie–Paris, France

Sebastien Fau

Université Pierre et Marie Curie–Paris, France, Service de Réanimation Néonatale et Pédiatrique, Hôpital Armand Trousseau, Université Pierre et Marie Curie–Paris, France

Christiane Charriaut-Marlangue

Université Pierre et Marie Curie–Paris, France, Christiane.Marlangue{at}snv.jussieu.fr

Many central nervous system (CNS) diseases display sexual dimorphism, specifically a predilection for one gender or a gender-dependent response to treatment. Exposure to circulating sex steroids is felt to be a chief contributor to this phenomenon. However, CNS diseases of childhood and of the elderly also demonstrate gender predominance and/or sexual dimorphism response to therapies. In this short update, we provide information concerning one of the most interesting new emerging concepts related to the influence of the sex in the pathogenesis of developmental brain injuries leading to different levels of neuroprotection between genders after cerebral hypoxia-ischemia or ischemia. NEUROSCIENTIST 14(1):46—52, 2008. DOI: 10.1177/1073858407308889

Key Words: Female • Male • Caspase inhibitor • Mitochondria • Cytochrome c • Cell death


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