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The Neuroscientist
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Morphine: A Protective or Destructive Role in Neurons?

Yan Zhang

Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology College of Life Sciences, Peking University, Beijing, China, yulc{at}pku.edu.cn

Qiuyue Chen

Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology College of Life Sciences, Peking University, Beijing, China

Long-Chuan Yu

Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology College of Life Sciences, Peking University, Beijing, China

Morphine has received intensive research interest for a long time. However, until recently, the protective versus destructive roles of morphine in the neuronal system have not been studied. There is evidence suggesting that morphine induces apoptotic cell death in neuronal and glial cells, whereas controversial studies support a neuroprotective role for morphine. The exact mechanisms for both protective and destructive pathways are not clear and are still under investigation. Improved understanding of morphine neuroprotection and neurotoxicity will be helpful to control morphine side effects in medical applications and to identify new targets for potential therapies and prevention strategies to opioid addiction. NEUROSCIENTIST 14(6):561-570, 2008. DOI:

Key Words: Morphine • Protection • Toxicity • Apoptosis • Neurons

This version was published on December 1, 2008

The Neuroscientist, Vol. 14, No. 6, 561-570 (2008)
DOI: 10.1177/1073858408314434
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