| Sign In to gain access to subscriptions and/or personal tools. |
Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and PlasticityCurriculum in Neurobiology, Neuroscience Center, and Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill
Systems Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA
Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, dfeldman{at}berkeley.edu
Curriculum in Neurobiology, Neuroscience Center, and Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill Many aspects of synaptic development, plasticity, and neurotransmission are critically influenced by NMDAtype glutamate receptors (NMDARs). Moreover, dysfunction of NMDARs has been implicated in a broad array of neurological disorders, including schizophrenia, stroke, epilepsy, and neuropathic pain. Classically, NMDARs were thought to be exclusively postsynaptic. However, substantial evidence in the past 10 years demonstrates that NMDARs also exist presynaptically and that presynaptic NMDA receptors (preNMDARs) modulate synapse function and have critical roles in plasticity at many synapses. Here the authors review current knowledge of the role of preNMDARs in synaptic transmission and plasticity, focusing on the neocortex. They discuss the prevalence, function, and development of these receptors, and their potential modification by experience and in brain pathology.
Key Words: Presynaptic NMDA receptors • Timing-dependent long-term depression • Spike timing-dependent plasticity • Cortex • Development
The Neuroscientist, Vol. 14, No. 6,
609-625 (2008) This article has been cited by other articles:
|
|||||||||||||||
 |
|
|
 |
Sign In to gain access to subscriptions and/or personal tools.
