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The Neuroscientist
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*Alzheimer's Disease
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The Role of the p75 Neurotrophin Receptor in Cholinergic Dysfunction in Alzheimer's Disease

E.J. Coulson

Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia, e.coulson{at}uq.edu.au

L.M. May

Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia

A.M. Sykes

Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia

A.S. Hamlin

Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia

Degeneration of basal forebrain cholinergic neurons is a common feature of Alzheimer's disease and is proposed to be an early and key event in the condition's etiology. This review discusses recent findings that strongly link the p75 neurotrophin receptor (p75 NTR) to both cholinergic neuron degeneration and the production of toxic forms of amyloid-beta (Aß), which is found deposited as amyloid plaques in the brains of Alzheimer's disease patients. Although elucidating the underlying molecular mechanisms and the clinical significance of these findings will require further experimentation, a number of possible scenarios and future research directions are presented.

Key Words: Alzheimer's disease • basal forebrain cholinergic neuron • neurotrophins • transgenic mouse models • neurodegeneration

This version was published on August 1, 2009

The Neuroscientist, Vol. 15, No. 4, 317-323 (2009)
DOI: 10.1177/1073858408331376
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