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The Neuroscientist
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{blacksquare} REVIEW : Glial NO: Normal and Pathological Roles

Sean Murphy

Department of Pharmacology

Dana Grzybicki

Department of Pathology University of Iowa College of Medicine Iowa City, Iowa

All nervous system cell types can be induced with cytokines or bacterial products to make nitric oxide, at least in culture. The signaling pathways invoked by inducers that result in transcriptional activation of the nitric oxide synthase gene are becoming clear, and modulators of this induction have been discovered. Much suggestive and, recently, more definitive evidence has accumulated for induction of nitric oxide synthase in glial cells in vivo associated with viral infection, as well as in animal models of trauma, ischemia, and autoimmunity. Whether nitric oxide from this source contributes to or limits the attendant conditions is not yet clear. The Neuroscientist 2:90-99, 1996

Key Words: KEY WORDS Nitric oxide synthase • Astrocyte • Microglia • Cytokines • Neuropathologies • Cerebrovasculature

The Neuroscientist, Vol. 2, No. 2, 90-99 (1996)
DOI: 10.1177/107385849600200210


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This article has been cited by other articles:


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J. Pharmacol. Exp. Ther.Home page
J. D. Militante, D. L. Feinstein, and P. J. Syapin
Suppression by Ethanol of Inducible Nitric Oxide Synthase Expression in C6 Glioma Cells
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[Abstract] [Full Text]



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