This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bredesen, D. E. Search for Related Content PubMed Articles by Bredesen, D. E. Social Bookmarking                   What's this?

REVIEW : Keeping Neurons Alive: The Molecular Control of Apoptosis (Part I

Program on Aging La Jolla Cancer Research Foundation La Jolla, California

Apoptosis is a form of cellular suicide in which the cell activates an intrinsic program to bring about its own demise. Recognized for years as the mechanism by which developing cells are lost naturally, it has become apparent recently that this same process may play an important role in many acute and chronic diseases in which neural cell death occurs, such as stroke and Alzheimer's disease. This growing recognition suggests that a knowledge of the gene products controlling this process may lead to improved treatments for some disease states, as well as to improved understanding of neuronal development, physiology, and pathophysiology. Some controls with important roles in neural apoptosis have been identified, and these controls, as well as their putative mechanisms of action, are described in this article. NEUROSCIENTIST 2:181-190, 1996

Key Words: KEY WORDS Programmed cell death • Bcl-2 • Endonuclease • Neurodegeneration • Reactive oxygen species • Cysteine protease

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. S. Beattie, S. L. Shuman, and J. C. Bresnahan Review : Apoptosis and Spinal Cord Injury Neuroscientist, May 1, 1998; 4(3): 163 - 171. [Abstract] [PDF]