This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Zigmond, R. E. Search for Related Content PubMed Articles by Zigmond, R. E. Social Bookmarking                         What's this?

REVIEW : LIF, NGF, and the Cell Body Response to Axotomy

Department of Neurosciences Case Western Reserve University Cleveland, Ohio

Adult peripheral neurons can regenerate after axonal damage. Large changes in gene expression occur in the cell bodies of these axotomized neurons, including decreases in expression of a number of proteins used for synaptic transmission and increases in expression of a number of proteins involved in regeneration. The signals that trigger these changes are just beginning to be elucidated. One characteristic of axotomized sympathetic, sensory, and motor neurons is that they increase expression of two neuropeptides, vasoactive intestinal peptide and galanin. These peptides may play important roles in the survival and regeneration of axotomized neurons deprived of their target-derived trophic factors. Recent studies have demonstrated two important signals in the induction of these peptides in sympathetic neurons: one is the release of leukemia inhibitory factor (LIF) by non-neuronal cells in the vicinity of the injured neurons and the other, the removal of target-derived nerve growth factor (NGF). Furthermore, there is a synergistic interaction between these two events whereby the removal of NGF alters the responsiveness of neurons to LIF. Future efforts will hopefully determine the extent to which LIF and NGF signal other aspects of the cell body response and the mechanisms that underlie these actions. NEUROSCIENTIST 3:176-185, 1997

Key Words: KEY WORDS Axotomy • Cytokines • Leukemia inhibitory factor • Nerve growth factor • Neuropeptides • Regeneration

The Neuroscientist, Vol. 3, No. 3, 176-185 (1997)
DOI: 10.1177/107385849700300311


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				K. Drahushuk, T. D. Connell, and D. Higgins Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Peptide Inhibit Dendritic Growth in Cultured Sympathetic Neurons J. Neurosci., August 1, 2002; 22(15): 6560 - 6569. [Abstract] [Full Text] [PDF]

				A. M. Shadiack, S. A. Vaccariello, Y. Sun, and R. E. Zigmond Nerve growth factor inhibits sympathetic neurons' response to an injury cytokine PNAS, June 23, 1998; 95(13): 7727 - 7730. [Abstract] [Full Text] [PDF]