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The Spectrum and Pathogenesis of Antibody-mediated NeuropathiesLaboratory of Molecular and Cellular Neurobiology National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda, Maryland Antibodies reacting with carbohydrate epitopes on neural glycoconjugates are present in several forms of neuropathy. These include monoclonal antibodies to the myelin-associated glycoprotein (MAG) and to gan gliosides in patients with neuropathy in association with IgM gammopathy, as well as polyclonal antibodies to gangliosides in inflammatory polyneuropathies, such as Guillain-Barré syndrome and multifocal motor neuropathy. There are several correlations between antibody specificity and clinical symptoms, including anti-MAG antibodies with demyelinating sensory or sensorimotor neuropathy, anti-GM1 ganglioside anti bodies with motor nerve disorders, anti-GQ1b ganglioside antibodies with Miller-Fisher syndrome, and antibodies to gangliosides containing disialosyl moieties with sensory ataxic neuropathy. This review will emphasize recent developments concerning the origins of the anti-glycoconjugate antibodies in patients, pathogenic mechanisms by which the antibodies may cause the neuropathies, and the implications of these findings for therapy. NEUROSCIENTIST 3:195-204, 1997
Key Words: KEY WORDS Antibody • Ganglioside • Myelin-associated glycoprotein • Neuropathy • Sulfoglucuronyl paragloboside
The Neuroscientist, Vol. 3, No. 3,
195-204 (1997) This article has been cited by other articles:
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