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The Neuroscientist
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{blacksquare} REVIEW : Basic Fibroblast Growth Factor: A Treatment for stroke?

David A. Lin

CNS Growth Factor Research Laboratory Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts

Seth P. Finklestein

CNS Growth Factor Research Laboratory Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts

Basic fibroblast growth factor (bFGF) is a polypeptide with potent trophic effects on brain cells. In particular, bFGF promotes the survival and outgrowth of brain neurons, and protects neurons against toxic processes that are important contributors to cell death after cerebral ischemia (stroke). Recent studies in animal models have suggested two potential uses of exogenously administered bFGF for the treatment of stroke: 1) intra venous bFGF to reduce infarct size in acute stroke, and 2) intracisternal bFGF to enhance neurological recovery in chronic stroke. Human clinical trials of the first of these applications are currently in progress. NEUROSCIENTIST 3:247-250,1997

Key Words: KEY WORDS Basic fibroblast growth factor • Cerebral Ischemia • Stroke

The Neuroscientist, Vol. 3, No. 4, 247-250 (1997)
DOI: 10.1177/107385849700300412
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