The Neuroscientist

 

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The Neuroscientist, Vol. 4, No. 3, 195-201 (1998)
DOI: 10.1177/107385849800400315

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REVIEW {blacksquare} : Interleukin-1 and Neurodegeneration

Nancy J. Rothwell

School of Biological Sciences University of Manchester Manchester, United Kmgdom

The cytokine interleukin-1 (IL-1) has been implicated in many forms of neurodegeneration. Expression of IL-1 is increased in the brain (mainly by microglia) of animals and humans in response to acute insults (e.g., stroke and brain injury) and in chronic neurodegenerative conditions. Although IL-1 does not kill otherwise healthy neurons, small quantities of the cytokine dramatically enhance ischemic, traumatic, or excitotoxic damage in animals. Inhibition of the synthesis, release, or action of IL-1 (e.g., by administration of IL-1 receptor antagonist) markedly reduces all of these forms of experimental neurodegeneration, indicating that approaches to block or inhibit IL-1 activity may be of benefit in clinical neurodegenerative disease. NEURO SCIENTIST 4:195-201, 1998

Key Words: KEY WORDS Cytokmes • Interleukin-1 • Neurodegeneration


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