SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
The Neuroscientist
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Brodkin, E. S.
Right arrow Articles by Nestler, E. J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Brodkin, E. S.
Right arrow Articles by Nestler, E. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Other

Quantitative Trait Locus Analysis: A New Tool for Psychiatric Genetics

Edward S. Brodkin

Eric J. Nestler

This update provides a brief overview of the principles underlying quantitative trait locus (QTL) analysis and of the usefulness of this analysis as a new tool for psychiatric ge netics. We review the criteria by which inbred rodent strains are chosen for QTL analysis; the various breeding protocols that may be used in QTL analysis; the principles underlying the phenotyping and genotyping of animals; the statistical analysis by which genetic loci are identified; and, finally, the challenge of discovering the specific genes within the identified loci that affect the trait of interest. QTL analysis offers promise for advancing our understanding of the genetics of mammalian behavior and, ultimately, of the etiology of psychiatric disorders. NEUROSCIENTIST 4:317-323, 1998

Key Words: KEY WORDS Quantitative trait locus (QTL) • Psychiatric genetics • Behavioral genetics

The Neuroscientist, Vol. 4, No. 5, 317-323 (1998)
DOI: 10.1177/107385849800400511
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




Advertisement