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The Neuroscientist
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Autoimmunity to Glutamate Receptors in Rasmussen's Encephalitis: A Rare Finding or The Tip of an Iceberg?

Lorise C. Gahring

Salt Lake City Veteran's Administration Geriatrics Research, Education and Clinical Center (GRECC) University of Utah School of Medicine Salt Lake City, Utah

Scott W. Rogers

Salt Lake City Veteran's Administration Geriatrics Research, Education and Clinical Center (GRECC) University of Utah School of Medicine Salt Lake City, Utah

Neurological disorders demonstrate remarkable specificity in afflicting precise brain regions. They are most frequently sporadic in origin and they are devastating because of the progressive impairment of cognitive and/or motor functions. Our studies have found that some neurological diseases may actually reflect a dysfunction of the immune system in which highly specific autoantibodies are generated that bind neuronal glutamate receptors and directly affect their function in normal neurotransmission. Understanding at the molecular level how the immune system participates in neurological disease will ultimately lead to more effective therapeutic approaches to some of these disorders with presently unknown etiology. NEURO SCIENTIST 4:373-379, 1998

Key Words: KEY WORDS Receptors • Glutamate • Autoantibodies • Neurobiology • Epilepsy

The Neuroscientist, Vol. 4, No. 5, 373-379 (1998)
DOI: 10.1177/107385849800400519
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Home page
 J. Immunol.Home page
L. C. Gahring, N. G. Carlson, E. L. Meyer, and S. W. Rogers
Cutting Edge: Granzyme B Proteolysis of a Neuronal Glutamate Receptor Generates an Autoantigen and Is Modulated by Glycosylation
J. Immunol., February 1, 2001; 166(3): 1433 - 1438.
[Abstract] [Full Text] [PDF]


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