The Neuroscientist

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Snyder, E. Y.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Snyder, E. Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Neuroscientist, Vol. 4, No. 6, 408-425 (1998)
DOI: 10.1177/107385849800400613

Reviews

Review : Neural Stem-Like Cells: Developmental Lessons with Therapeutic Potential

Evan Y. Snyder

Departments of Neurology (Division of Neuroscience) and Pediatrics (Division of Newborn Medicine) Harvard Medical School Children's Hospital Boston, Massachusetts

It is possible, by a variety of means, to isolate, propagate, and characterize engraftable clones of cells from the mammalian CNS that fulfill the operational definition of a "stem cell": self-maintaining, self-renewing, and extremely multipotent in vitro and in vivo. Even as debates flourish over how neural stem cells might best be defined, identified, represented, and manipulated, clonal cells with "stem-like" features have begun to provide valuable models for studying commitment, differentiation, and plasticity in the CNS. Furthermore, by learning in this way the basic biology of neural stem cells, and by then exploiting those inherent properties for therapeutic ends, novel and multifaceted strategies seem poised to emerge for redressing a variety of heretofore untreatable CNS dysfunctions. Stem-like cells have begun to show promise for neural cell re placement and molecular support therapy in various animal models of degenerative, developmental, and acquired CNS insult. NEUROSCIENTIST 4:408-425, 1998

Key Words: KEY WORDS Neural progenitor and stem cells • Neural transplantation • Gene therapy • Neural degeneration and injury • Neural cell replacement • Neural lineage and cell type determination.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Virol.Home page
W. P. Lynch, A. H. Sharpe, and E. Y. Snyder
Neural Stem Cells as Engraftable Packaging Lines Can Mediate Gene Delivery to Microglia: Evidence from Studying Retroviral env-Related Neurodegeneration
J. Virol., August 1, 1999; 73(8): 6841 - 6851.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. D. Yandava, L. L. Billinghurst, and E. Y. Snyder
"Global" cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain
PNAS, June 8, 1999; 96(12): 7029 - 7034.
[Abstract] [Full Text] [PDF]