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The Neuroscientist
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Does CNS Myelin Inhibit Axon Regeneration?

R. Douglas Fields

Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health Bethesda, Maryland

Martin E. Schwab

Brain Research Institute, University of Zurich Swiss Federal Institute of Technology Zurich, Switzerland

Jerry Silver

Department of Neurosciences (JS) Case Western Reserve University Cleveland, Ohio

Membrane proteins on oligodendrocytes and CNS myelin (NI35/250) have been shown to block axon out growth in culture, and this is thought to be one of the major reasons for severely limited regeneration of severed axons in the CNS of higher vertebrates. In a recent study, adult dorsal root ganglion (DRG) neurons, which are sensitive to these inhibitory proteins, regenerated successfully after transplantation into two white matter tracts of the rat brain without any intervention to suppress the inhibitory activity of CNS myelin. The results and implications of these two studies are considered. NEUROSCIENTIST 5:12-18, 1999

Key Words: KEY WORDS NI35/250 • Axon regeneration • Proteoglycan • Gliosis • Oligodendrocytes • Astrocytes • Myelin • Spinal cord injury • Extra cellular matrix

The Neuroscientist, Vol. 5, No. 1, 12-18 (1999)
DOI: 10.1177/107385849900500103
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