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The Neuroscientist
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Cytokines and Virus Proteins: Modulators of Glial Electrophysiological Properties

Hubertus Köller

Hans-Georg Fischer

Cytokines are released during acute and chronic inflammatory diseases of the CNS and activate receptors on glial cells, thereby inducing various effects such as proliferation, expression of major histocompatibility complex genes or secretion of growth factors. Here, we summarize current evidence indicating that K+ currents, Ca 2+ currents, and the activity of ion transporters on astrocytes, microglial cells, and oligodendrocytes are also affected by cytokines. In disease states with associated elevated cytokine titers, such alterations in electrophysiological properties of glial cells might contribute to the patho genesis of neurological symptoms. NEUROSCIENTIST 5:142-146, 1999

Key Words: KEY WORDS Glial cells • Cytokines • Inflammatory CNS diseases • Potassium currents

The Neuroscientist, Vol. 5, No. 3, 142-146 (1999)
DOI: 10.1177/107385849900500310
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