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The Neuroscientist
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Review : Cell Cycle as Operational Unit of Neocortical Neuronogenesis

T. Takahashi

Department of Neurology Massachusetts General Hospital Harvard Medical School Boston, Massachusetts

R.S. Nowakowski

Department of Neuroscience and Cell Biology UMDNJ-Robert Wood Johnson Medical School Piscataway, New Jersey

V.S. Caviness, Jr

Department of Neurology Massachusetts General Hospital Harvard Medical School Boston, Massachusetts

Neuronogenesis in the ventricular epithelium is the initial process in a succession of histogenetic events that give rise to the laminate neocortex. Herein, we review experimental findings in mouse that support the thesis that cell cycle is the operational unit of the neuronogenetic sequence. We show that the principal regulated parameters of proliferation progress uniformly as functions of cycle number and are independent of location in the proliferative epithelium. These parameters are the duration of the G1 phase of the cell cycle and Q, the fraction of cells that leaves the cycle after mitosis. Furthermore, the specification of neuronal class and possibly also specification of a regional protomap occur coordinately with cell cycle across the expanse of the proliferative epithelium. This coordinate progression of histogenetic events with cell cycles invites the hypothesis that the mechanisms of cell cycle regulation are interdependent in proliferative cells. NEUROSCIENTIST 5:155-163, 1999

Key Words: KEY WORDS Cell cycle • Neocortical neuronogenesis • Neocortical histogenesis • Mouse neocortex

The Neuroscientist, Vol. 5, No. 3, 155-163 (1999)
DOI: 10.1177/107385849900500312
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