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The Neuroscientist
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Review : Remyelination—A Regenerative Process in the CNS

Robin J.M. Franklin

Department of Clinical Veterinary Medicine University of Cambridge Cambridge, UK

CNS remyelination is a regenerative process that contrasts with the more widely recognized absence of regeneration characteristic of neuronal injury. This important process both restores saltatory conduction to demyelinated axons and enables the recovery of functions mediated by impulse conduction in those axons. Unfortunately, remyelination can be a fragile process that is prone to fail, contributing to the persistence of clinical deficits in patients with demyelinating disease. Despite being first described more than 30 years ago, it is only relatively recently that a clearer (though still incomplete) picture of the cellular and molecular mechanisms of remyelination has begun to emerge. These developments, in particular the role of the oli godendrocyte progenitor, have provided insights into why remyelination sometimes fails and will provide the basis for enhancing this process by means of therapeutic intervention. NEUROSCIENTIST 5:184-191, 1999

Key Words: KEY WORDS Demyelination • Remyelination • Oligodendrocyte • Progenitor

The Neuroscientist, Vol. 5, No. 3, 184-191 (1999)
DOI: 10.1177/107385849900500315
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This article has been cited by other articles:


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 BrainHome page
J. Penderis, S. A. Shields, and R. J. M. Franklin
Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system
Brain, June 1, 2003; 126(6): 1382 - 1391.
[Abstract] [Full Text] [PDF]


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