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The Neuroscientist, Vol. 6, No. 1, 39-47 (2000)
DOI: 10.1177/107385840000600112

Reviews

Review {blacksquare} : Insulin-like Growth Factor-I and Apoptosis in Glial Cell Biology

Catherine L. Delaney

Department of Neurology University of Michigan Ann Arbor, Michigan

Eva L. Feldman

Department of Neurology University of Michigan Ann Arbor, Michigan

Insulin-like growth factor-I (IGF-I) is a potent trophic factor capable of promoting both survival and differentiation of neurons and glia. This review examines the role of IGF-I and apoptosis in oligodendrocyte and Schwann cell biology in vitro and in vivo. Apoptosis is an essential element of development, homeostasis, and disease. IGF-I protects oligodendrocytes and Schwann cells from apoptosis during development and after apoptotic stimuli. Transgenic mouse models, which ablate or increase expression of IGF-I, have abnormal oligodendrocytes and myelin formation. A more thorough understanding of the protective mechanism of IGF-I in oligodendrocytes and Schwann cells will aid in its precise application in treating a variety of neurologic disorders. NEUROSCIENTIST 6:39-47, 2000

Key Words: Schwann cell, • Oligodendrocyte, • Apoptosis, • Myelin, • Insulin-like growth factor-I (IGF-I), • Glia


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