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Dopamine Receptors: Novel Insights from Biochemical and Genetic StudiesDepartment of Psychiatry/Neuroscience, Columbia University, New York, NY Dopamine receptors are targets for drugs with antipsychotic potency, and they are also the primary target in the treatment of Parkinson’s disease. Molecular cloning has identified five genes that code for dopamine receptors. These receptors belong in two functionally distinct classes of G-protein-coupled receptors, known as the D1 class of receptors (D1 and D5) and the D2 class of receptors (D2, D3, and D4). The diversity of dopamine receptor subtypes that belong to the same functional class, their high degree of structural similarity, and the lack of antagonists with selectivity for each of the individual subtypes have challenged studies on the function of the individual receptor subtypes. This review focuses on the recent progress made with studies on the expression and function of D1, D2, and D3 receptors. It summarizes results of studies that suggest that these receptor proteins are expressed in monomeric and oligomeric forms and reviews results of a growing number of gene-targeting studies that begin to illustrate major differences in the phenotypes of D1-, D2-, and D3-mutant mice.
Key Words: Dopamine receptors • Oligomeric assembly • Gene targeting • Homologous recombination
The Neuroscientist, Vol. 6, No. 2,
127-138 (2000) |
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