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The Neuroscientist
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Is There a Neuropathology of Schizophrenia? Recent Findings Converge on Altered Thalamic-Prefrontal Cortical Connectivity

David A. Lewis

Departments of Psychiatry and Neuroscience University of Pittsburgh Pittsburgh, Pennsylvania, lewisda{at}msx.upmc.edu

Schizophrenia is a serious and chronic brain disorder whose underlying neuropathology has proven difficult to identify. This article reviews the current status of neuropathological studies in terms of how they inform the diagnosis, pathogenesis, pathophysiology, and mechanisms of treatment of schizophrenia. Although additional studies are required, substantial data converge on the hypothesis that the pathophysiology of schizophrenia is associated with alterations in thalamic-prefrontal cortical connectivity.

Key Words: Schizophrenia • Prefrontal cortex • Mediodorsal thalamus • Dopamine • GABA • Pyramidal neuron

The Neuroscientist, Vol. 6, No. 3, 208-218 (2000)
DOI: 10.1177/107385840000600311
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