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The Neuroscientist
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Neuregulins and the Shaping of Synapses

Miwako Ozaki

Laboratory for Cellular Information Processing, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), Japan, mozaki{at}postman.riken.go.jp

In developing and mature neural circuits, neural electrical activity controls the correct formation of connections and their state. Neuregulins (NRGs) mediate between the electrical neural activity and molecular components by regulating the expression of ion channel receptors or transmitter release in synapses. Furthermore, NRGs may be signaling factors involved in tuning locomotion or other higher functions by coordinating excitatory and inhibitory neurons.

Key Words: Neuregulin • ErbB • NMDA receptor • GABAA receptor • Synapse • Activity-dependent

The Neuroscientist, Vol. 7, No. 2, 146-154 (2001)
DOI: 10.1177/107385840100700209
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This article has been cited by other articles:


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R. Wiersma-Meems, J. Van Minnen, and N. I. Syed
Synapse Formation and Plasticity: The Roles of Local Protein Synthesis
Neuroscientist, June 1, 2005; 11(3): 228 - 237.
[Abstract] [PDF]


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