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Book Review: The Neurobiology of Pain: Developmental Aspects
Maria Fitzgerald
Department of Anatomy & Developmental Biology, University College, London, m.fitzgerald{at}ucl.ac.uk
Simon Beggs
AI Virtanen Institute, University of Kuopio, Finland
Invasive procedures that would be painful in children and adults are frequently performed on infants admitted to the neonatal intensive care unit. This article discusses sensory responses to these procedures in the immature nervous system and highlights the fact that, in addition to causing distress and delayed recovery, pain in infancy is also a developmental issue. First, the immaturity of sensory processing within the newborn spinal cord leads to lower thresholds for excitation and sensitization, therefore potentially maximizing the central effects of these tissue-damaging inputs. Second, the plasticity of both peripheral and central sensory connections in the neonatal period means that early damage in infancy can lead to prolonged structural and functional alterations in pain pathways that can last into adult life.
Key Words: Infant pain • Pediatric pain • Hyperalgesia • Allodynia • Spinal cord • Sensory neuron • C fibers • Inflammation • Neuropathic pain • Analgesia
The Neuroscientist, Vol. 7, No. 3,
246-257 (2001)
DOI: 10.1177/107385840100700309
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