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The Neuroscientist
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The Central Noradrenaline System and Memory Consolidation

Kazuto Kobayashi

Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1297, Japan, kazuto{at}fmu.ac.jp

Yasunobu Yasoshima

Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1297, Japan

Long-term memory requires de novo protein synthesis and gene expression, which are mediated by certain intracellular signaling pathways. The noradrenaline (NA) system in the CNS is involved in a wide variety of neurological and psychological functions. In addition to previous pharmacological studies, a recent molecular genetic approach provides behavioral evidence for an essential role of the central NA system in long-term memory formation, particularly in memory consolidation. The potential cellular and molecular mechanisms underlying memory formation mediated by NA are discussed.

Key Words: Noradrenaline • Adrenergic receptor • Conditioned learning • Long-term memory • Memory consolidation

The Neuroscientist, Vol. 7, No. 5, 371-376 (2001)
DOI: 10.1177/107385840100700506
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