SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
The Neuroscientist
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Hayaishi, O.
Right arrow Articles by Urade, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hayaishi, O.
Right arrow Articles by Urade, Y.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Prostaglandin D2 in Sleep-Wake Regulation: Recent Progress and Perspectives

Osamu Hayaishi

Osaka Bioscience Institute, Osaka 565-0874, Japan, hayaishi{at}obi.or.jp

Yoshihiro Urade

Osaka Bioscience Institute, Osaka 565-0874, Japan

Prostaglandin (PG) D2 is one of the most active endogenous sleep-promoting substances, which induces physiological sleep in rodents, primates, and most probably in humans as well. In this update article, we review recent experimental results concerning the molecular mechanisms underlying sleep-wake regulation by PGD2, the link between the humoral regulation by the PGD2 system, and the neural network involved in the promotion of non-rapid eye movement (NREM) sleep and the abnormality of NREM sleep regulation found in gene-manipulated mice for PGD synthase.

Key Words: Prostaglandin (PG) D2 • PGD synthase • PGD receptor • Sleep • Adenosine

The Neuroscientist, Vol. 8, No. 1, 12-15 (2002)
DOI: 10.1177/107385840200800105
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
N. Uozumi, Y. Kita, and T. Shimizu
Modulation of Lipid and Protein Mediators of Inflammation by Cytosolic Phospholipase A2{alpha} during Experimental Sepsis
J. Immunol., September 1, 2008; 181(5): 3558 - 3566.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. A. Lovell, B. C. Lynn, S. Xiong, J. F. Quinn, J. Kaye, and W. R. Markesbery
An aberrant protein complex in CSF as a biomarker of Alzheimer disease
Neurology, June 3, 2008; 70(23): 2212 - 2218.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Joo, M. Kwon, R. T. Sadikot, P. J. Kingsley, L. J. Marnett, T. S. Blackwell, R. S. Peebles Jr, Y. Urade, and J. W. Christman
Induction and Function of Lipocalin Prostaglandin D Synthase in Host Immunity
J. Immunol., August 15, 2007; 179(4): 2565 - 2575.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. J. A. Helliwell, J. A. Keelan, K. W. Marvin, L. Adams, M. C. Chang, A. Anand, T. A. Sato, S. O'Carroll, T. Chaiworapongsa, R. J. Romero, et al.
Gestational Age-Dependent Up-Regulation of Prostaglandin D Synthase (PGDS) and Production of PGDS-Derived Antiinflammatory Prostaglandins in Human Placenta
J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 597 - 606.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Fujimori, K. Kadoyama, and Y. Urade
Protein Kinase C Activates Human Lipocalin-type Prostaglandin D Synthase Gene Expression through De-repression of Notch-HES Signaling and Enhancement of AP-2{beta} Function in Brain-derived TE671 Cells
J. Biol. Chem., May 6, 2005; 280(18): 18452 - 18461.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
O. Saydam, C. Abril, B. Vogt, M. Ackermann, and M. Schwyzer
Transactivator Protein BICP0 of Bovine Herpesvirus 1 (BHV-1) Is Blocked by Prostaglandin D2 (PGD2), Which Points to a Mechanism for PGD2-Mediated Inhibition of BHV-1 Replication
J. Virol., April 15, 2004; 78(8): 3805 - 3810.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
Y. Urade, N. Eguchi, W.-M. Qu, M. Sakata, Z.-L. Huang, J.-F. Chen, M. A. Schwarzschild, J. S. Fink, and O. Hayaishi
Minireview: Sleep regulation in adenosine A2A receptor-deficient mice
Neurology, December 9, 2003; 61(90116): S94 - 96.
[Full Text]

Home page
 J. Biol. Chem.Home page
K. Fujimori, Y. Fujitani, K. Kadoyama, H. Kumanogoh, K. Ishikawa, and Y. Urade
Regulation of Lipocalin-type Prostaglandin D Synthase Gene Expression by Hes-1 through E-box and Interleukin-1beta via Two NF-kappa B Elements in Rat Leptomeningeal Cells
J. Biol. Chem., February 14, 2003; 278(8): 6018 - 6026.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
D. Irikura, T. Kumasaka, M. Yamamoto, H. Ago, M. Miyano, K. B. Kubata, H. Sakai, O. Hayaishi, and Y. Urade
Cloning, Expression, Crystallization, and Preliminary X-Ray Analysis of Recombinant Mouse Lipocalin-type Prostaglandin D Synthase, a Somnogen-Producing Enzyme
J. Biochem., January 1, 2003; 133(1): 29 - 32.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Taniike, I. Mohri, N. Eguchi, C. T. Beuckmann, K. Suzuki, and Y. Urade
Perineuronal Oligodendrocytes Protect against Neuronal Apoptosis through the Production of Lipocalin-Type Prostaglandin D Synthase in a Genetic Demyelinating Model
J. Neurosci., June 15, 2002; 22(12): 4885 - 4896.
[Abstract] [Full Text] [PDF]


Advertisement