|
Sign In to gain access to subscriptions and/or personal tools.
|
The Neuroscientist, Vol. 8, No. 2,
122-131 (2002)
Protein Kinase Signal Transduction Cascades in Mammalian Associative Conditioning
Joel C. Selcher
Edwin J. Weeber
Andrew W. Varga
J. David Sweatt
Michael Swank
One of the most intriguing and intensely studied questions facing contemporary neuroscientists involves the elucidation of the physiological mechanisms that underlie learning and memory. Recent advances have given us a much more detailed understanding of the signal transduction mechanisms subserving learning in the intact animal. One fact that has become clear is that activation of protein kinases and phosphorylation of their downstream effectors play a critical role. Four protein kinase cascades have garnered considerable attention in the study of information storage at both the synaptic and behavioral levels: Ca++ /phospholipid-dependent protein kinase (PKC), Ca++ /calmodulin-dependent protein kinase II (CaMKII), cAMP-dependent protein kinase (PKA), and extracellular signal-regulated kinase (ERK). This review will concentrate on studies of two behavioral tasks, conditioned fear and conditioned taste aversion, that provide evidence for the involvement of these kinase systems in associative learning. The authors will also examine a number of potential kinase substrates and how each could participate in the formation of long-term memories.
Key Words: learning • memory • MAP kinase • PKC • PKA • CaMKII • ERK • Kv4.2 • acetyltransferase • CREB • fear conditioning • conditioned taste aversion
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. E. Canal, Q. Chang, and P. E. Gold
Intra-amygdala injections of CREB antisense impair inhibitory avoidance memory: Role of norepinephrine and acetylcholine
Learn. Mem.,
August 26, 2008;
15(9):
677 - 686.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Michel, I. Kemenes, U. Muller, and G. Kemenes
Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning
Learn. Mem.,
August 26, 2008;
15(9):
694 - 702.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Bruel-Jungerman, S. Davis, and S. Laroche
Brain Plasticity Mechanisms and Memory: A Party of Four
Neuroscientist,
October 1, 2007;
13(5):
492 - 505.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. Rinaman and V. Dzmura
Experimental dissociation of neural circuits underlying conditioned avoidance and hypophagic responses to lithium chloride
Am J Physiol Regulatory Integrative Comp Physiol,
October 1, 2007;
293(4):
R1495 - R1503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-C. Kim, H.-G. Lee, and K.-A. Han
D1 Dopamine Receptor dDA1 Is Required in the Mushroom Body Neurons for Aversive and Appetitive Learning in Drosophila
J. Neurosci.,
July 18, 2007;
27(29):
7640 - 7647.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Levenson, T. L. Roth, F. D. Lubin, C. A. Miller, I-C. Huang, P. Desai, L. M. Malone, and J. D. Sweatt
Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus
J. Biol. Chem.,
June 9, 2006;
281(23):
15763 - 15773.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. Thomas, G. R. Rumbaugh, D. B. Harrar, and R. L. Huganir
Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission
PNAS,
October 18, 2005;
102(42):
15006 - 15011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Cartford, T. Gould, and P. C. Bickford
A Central Role for Norepinephrine in the Modulation of Cerebellar Learning Tasks
Behav Cogn Neurosci Rev,
June 1, 2004;
3(2):
131 - 138.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. McCahill, J. Warwicker, G. B. Bolger, M. D. Houslay, and S. J. Yarwood
The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response Mechanisms
Mol. Pharmacol.,
December 1, 2002;
62(6):
1261 - 1273.
[Full Text]
[PDF]
|
|
|
|
