This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Selcher, J. C. Articles by Swank, M. Search for Related Content PubMed PubMed Citation Articles by Selcher, J. C. Articles by Swank, M. Social Bookmarking                         What's this?

Book Review: Protein Kinase Signal Transduction Cascades in Mammalian Associative Conditioning

Division of Neuroscience and Department of Genetics, Baylor College of Medicine, Houston, Texas

Edwin J. Weeber

Division of Neuroscience and Department of Genetics, Baylor College of Medicine, Houston, Texas

Andrew W. Varga

Division of Neuroscience and Department of Genetics, Baylor College of Medicine, Houston, Texas

J. David Sweatt

Division of Neuroscience and Department of Genetics, Baylor College of Medicine, Houston, Texas, jsweatt{at}bcm.tmc.edu

Michael Swank

Division of Neuroscience and Department of Genetics, Baylor College of Medicine, Houston, Texas

One of the most intriguing and intensely studied questions facing contemporary neuroscientists involves the elucidation of the physiological mechanisms that underlie learning and memory. Recent advances have given us a much more detailed understanding of the signal transduction mechanisms subserving learning in the intact animal. One fact that has become clear is that activation of protein kinases and phosphorylation of their downstream effectors play a critical role. Four protein kinase cascades have garnered considerable attention in the study of information storage at both the synaptic and behavioral levels: Ca⁺⁺/phospholipid-dependent protein kinase (PKC), Ca⁺⁺/calmodulin-dependent protein kinase II (CaMKII), cAMP-dependent protein kinase (PKA), and extracellular signal-regulated kinase (ERK). This review will concentrate on studies of two behavioral tasks, conditioned fear and conditioned taste aversion, that provide evidence for the involvement of these kinase systems in associative learning. The authors will also examine a number of potential kinase substrates and how each could participate in the formation of long-term memories.

Key Words: Learning • Memory • MAP kinase • PKC • PKA • CaMKII • ERK • Kv4.2 • Acetyltransferase • CREB • Fear conditioning • Conditioned taste aversion

The Neuroscientist, Vol. 8, No. 2, 122-131 (2002)
DOI: 10.1177/107385840200800208


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				B. Balasubramanian, W. Portillo, A. Reyna, J. Z. Chen, A. N. Moore, P. K. Dash, and S. K. Mani Nonclassical Mechanisms of Progesterone Action in the Brain: I. Protein Kinase C Activation in the Hypothalamus of Female Rats Endocrinology, November 1, 2008; 149(11): 5509 - 5517. [Abstract] [Full Text] [PDF]

				C. E. Canal, Q. Chang, and P. E. Gold Intra-amygdala injections of CREB antisense impair inhibitory avoidance memory: Role of norepinephrine and acetylcholine Learn. Mem., August 26, 2008; 15(9): 677 - 686. [Abstract] [Full Text] [PDF]

				M. Michel, I. Kemenes, U. Muller, and G. Kemenes Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning Learn. Mem., August 26, 2008; 15(9): 694 - 702. [Abstract] [Full Text] [PDF]

				E. Bruel-Jungerman, S. Davis, and S. Laroche Brain Plasticity Mechanisms and Memory: A Party of Four Neuroscientist, October 1, 2007; 13(5): 492 - 505. [Abstract] [PDF]

				L. Rinaman and V. Dzmura Experimental dissociation of neural circuits underlying conditioned avoidance and hypophagic responses to lithium chloride Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1495 - R1503. [Abstract] [Full Text] [PDF]

				Y.-C. Kim, H.-G. Lee, and K.-A. Han D1 Dopamine Receptor dDA1 Is Required in the Mushroom Body Neurons for Aversive and Appetitive Learning in Drosophila J. Neurosci., July 18, 2007; 27(29): 7640 - 7647. [Abstract] [Full Text] [PDF]

				J. M. Levenson, T. L. Roth, F. D. Lubin, C. A. Miller, I-C. Huang, P. Desai, L. M. Malone, and J. D. Sweatt Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus J. Biol. Chem., June 9, 2006; 281(23): 15763 - 15773. [Abstract] [Full Text] [PDF]

				G. M. Thomas, G. R. Rumbaugh, D. B. Harrar, and R. L. Huganir Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission PNAS, October 18, 2005; 102(42): 15006 - 15011. [Abstract] [Full Text] [PDF]

				M. C. Cartford, T. Gould, and P. C. Bickford A Central Role for Norepinephrine in the Modulation of Cerebellar Learning Tasks Behav Cogn Neurosci Rev, June 1, 2004; 3(2): 131 - 138. [Abstract] [PDF]

				A. McCahill, J. Warwicker, G. B. Bolger, M. D. Houslay, and S. J. Yarwood The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response Mechanisms Mol. Pharmacol., December 1, 2002; 62(6): 1261 - 1273. [Full Text] [PDF]