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The Neuroscientist, Vol. 8, No. 2, 93-97 (2002)
© 2002 SAGE Publications

Regulation of the Cell Cycle in Normal and Pathological Glia

Beth Stevens

Laboratory of Cellular and Synaptic Neurophysiology, National Institutes of Health, NICHD, Bethesda, Maryland

R. Douglas Fields

Laboratory of Cellular and Synaptic Neurophysiology, National Institutes of Health, NICHD, Bethesda, Maryland

Precise regulation of the glial cell cycle is essential during nervoussystem development and in response to injury, whereas disruption ofcell cycle control is associated with malignant glial tumors and othernervous system diseases. The Ras signaling pathway plays a centralrole in regulating the mammalian cell cycle, and uncontrolled Ras signalinghas been implicated in a wide range of human cancers, includingmalignant gliomas. Recent studies in glia have demonstrated thatactivation of Ras can either induce or inhibit proliferation throughcomplex interactions among downstream signaling pathways impingingon cell cycle regulatory proteins. Studies in Schwann cells havebegun to delineate the pathways by which Ras regulates the cell cyclein normal and pathological glia, and have identified promising targetsfor therapeutic intervention in the treatment of PNS and CNS malignantglial tumors.

Key Words: Ras • glioma • neurofibromatosis-type 1 (NF1) • Schwann cell • cyclin-dependent kinase inhibitor • tumor suppressor protein


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