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Book Review: Na+ Signals at Central Synapses

Physiological Institute University of Munich Germany, rose{at}lrz.uni-muenchen.de

A basic characteristic of animal cells is the maintenance of a steep inwardly directed electrochemical gradient for sodium ions. In vertebrate neurons, this Na⁺ gradient energizes intracellular ion regulation and enables influx of Na⁺ during action potentials and excitatory postsynaptic currents. Several studies suggested that Na⁺ ions could also play a role in activity-dependent synaptic plasticity. This review focuses on recent studies that demonstrated the presence of substantial intracellular Na⁺ transients during action potential firing or excitatory synaptic transmission in postsynaptic dendrites and dendritic spines. The large amplitudes of these activity-induced Na⁺ transients suggest that this signal will significantly alter electrical and biochemical properties of spines and dendrites and might influence the properties of synaptic transmission.

Key Words: Sodium • Synapse • Spine • Dendrite • SBFI

The Neuroscientist, Vol. 8, No. 6, 532-539 (2002)
DOI: 10.1177/1073858402238512


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