This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Velazquez, J. L. P. Articles by Naus, C. C. Search for Related Content PubMed PubMed Citation Articles by Velazquez, J. L. P. Articles by Naus, C. C. Social Bookmarking                         What's this?

Gap Junctions and Neuronal Injury: Protectants or Executioners?

Marina V. Frantseva

Christian C. Naus

The authors review concepts and recent experimental observations that relate gap junctional communication to the pathophysiology of neuronal injury, specifically ischemic or traumatic damage. The role played by this type of direct intercellular communication during the progression of the injuries can be conceived to be either detrimental or beneficial, depending on the arguments employed. The data indicate that, far from being a simple matter of judgment, the contribution of gap junctions to cell injury is a complicated phenomenon that depends on the specific insult and network in which it operates.

Key Words: Brain • Connexins • Gap junctions • Ischemia • Trauma

The Neuroscientist, Vol. 9, No. 1, 5-9 (2003)
DOI: 10.1177/1073858402239586


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. Hanstein, J. Trotter, C. Behl, and A. B. Clement Increased Connexin 43 Expression as a Potential Mediator of the Neuroprotective Activity of the Corticotropin-Releasing Hormone Mol. Endocrinol., September 1, 2009; 23(9): 1479 - 1493. [Abstract] [Full Text] [PDF]

				J. E. Cook and D. L. Becker Gap-Junction Proteins in Retinal Development: New Roles for the "Nexus" Physiology, August 1, 2009; 24(4): 219 - 230. [Abstract] [Full Text] [PDF]

				V. V. Yevseyenkov, S. Das, D. Lin, L. Willard, H. Davidson, A. Sitaramayya, F. J. Giblin, L. Dang, and D. J. Takemoto Loss of Protein Kinase C{gamma} in Knockout Mice and Increased Retinal Sensitivity to Hyperbaric Oxygen Arch Ophthalmol, April 1, 2009; 127(4): 500 - 506. [Abstract] [Full Text] [PDF]

				M. A. Retamal, N. Froger, N. Palacios-Prado, P. Ezan, P. J. Saez, J. C. Saez, and C. Giaume Cx43 Hemichannels and Gap Junction Channels in Astrocytes Are Regulated Oppositely by Proinflammatory Cytokines Released from Activated Microglia J. Neurosci., December 12, 2007; 27(50): 13781 - 13792. [Abstract] [Full Text] [PDF]

				J. C. de Rivero Vaccari, R. A. Corriveau, and A. B. Belousov Gap Junctions Are Required for NMDA Receptor Dependent Cell Death in Developing Neurons J Neurophysiol, November 1, 2007; 98(5): 2878 - 2886. [Abstract] [Full Text] [PDF]

				M. H. de Pina-Benabou, V. Szostak, A. Kyrozis, D. Rempe, D. Uziel, M. Urban-Maldonado, S. Benabou, D. C. Spray, H. J. Federoff, P. K. Stanton, et al. Blockade of Gap Junctions In Vivo Provides Neuroprotection After Perinatal Global Ischemia Stroke, October 1, 2005; 36(10): 2232 - 2237. [Abstract] [Full Text] [PDF]