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The Neuroscientist, Vol. 12, No. 1, 16-28 (2006)
DOI: 10.1177/1073858405282417

Reviews

Dendritic Plasticity in the Adult Neocortex

Peter W. Hickmott

Department of Psychology, Interdepartmental Neuroscience Program, University of California at Riverside, peter.hickmott{at}ucr.edu

Iryna M. Ethell

Division of Biomedical Sciences, Interdepartmental Neuroscience Program, University of California at Riverside

Dendrites are a major determinant of how neurons integrate and process incoming information, and thus, they play a vital role in the functional properties of neural circuits. During the past 30 years, it has become clear that the functional organization of the adult neocortex (and other parts of the brain) is dynamic and can change in response to experimental manipulations that affect cortical activity patterns. A variety of changes in the cortical microcircuit, including changes in synaptic function, neuronal membrane properties, and axonal trajectories, are associated with these functional changes. In this review, the authors discuss changes in the structure of dendrites in the adult neocortex, the sorts of experimental manipulations that induce these changes, and some possible molecular mechanisms that may underlie the changes.

Key Words: Neocortex • Dendrites • Plasticity • Neurotrophins

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This Article
Right arrow Abstract Freely available
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Citing Articles
Right arrow Citing Articles via ISI Web of Science (9)
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Right arrow Articles by Hickmott, P. W.
Right arrow Articles by Ethell, I. M.
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PubMed
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Right arrow Articles by Hickmott, P. W.
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